INVESTIGATING THE BIOACTIVE POTENTIAL OF WEDELIA CHINENSIS LEAVES THROUGH IN VITRO CYTOTOXICITY SCREENING: AN OVERVIEW

Abstract

Wedelia chinensis, a medicinal herb traditionally used in Asian countries, has shown promising anticancer properties in various in vitro models. Several extracts from W. chinensis demonstrates significant cytotoxic effects against multiple cancer in vitro cell lines, including prostate, breast, and liver cancers. These effects are attributed to its rich phytochemical phytoconstituents, mainly wedelolactone, luteolin, and apigenin, which modulate key signalling pathways involved in cell proliferation, apoptosis, and inflammation. This plant extracts induce apoptosis, inhibit cell migration, and suppress the growth of cancerous cells without or less notable toxicity to normal physiological cells. The reported findings supports the potential of Wedelia chinensis as a natural source for developing anticancer therapeutics.

This review article focuses on the leaves derived extracts of Wedelia chinensis, with particular attention to in vitro cytotoxicity screening as a gateway to anticancer and related bioactivities. These benefits and appearance of cytotoxic activity of Wedelia chinensis based on the ethnobotanical usage of the plant, a thorough review of previous research work. The major classes of secondary metabolites was identified in its leaves, such as diterpenoids and flavonoids would be responsible for cytotoxic activity. This review summarizes methods of in vitro cytotoxic activity and phytochemical investigation of Wedelia chinensis leaves.